Use of Cfp-10- Antigen with Fcγ2α Igg for Vaccine against Tuberculosis: Effective or Non-effective?
نویسندگان
چکیده
Tuberculosis (TB), a major public health problem, is a re-emerging challenging through the world. Prevention of this disease is a priority of WHO. Many subunit vaccine have been candidate for vaccination. Evaluating the safety and efficacy of these antigens is the concern of many researchers. This review is discussed efficiency or non-efficiency of CFP-10antigen with Fcγ2α IgG for vaccine design against tuberculosis.
منابع مشابه
Quantiation of IL-4, IL-10 and IFN- Genes Expression after Immunization of Mice with CFP-10 and ESAT-6 Containing Vectors
Background: Tuberculosis is a disease with high morbidity, caused mainly by Mycobaterium tuberculosis (M.tb.). DNA vaccines show a promising future due to their unique advantages over conventional methods. The early-secreted antigen target (ESAT)-6 and culture filtrate protein (CFP)-10 of M.tb. antigens have been identified as vaccine candidates against Mycobacteria and used as subunit vaccines...
متن کاملمقایسه پاسخهای ایمنی همورال متعاقب تجویز آنتیژن نوترکیب ESAT-6/CFP-10 مایکوباکتریوم توبرکلوزیس در سه مسیر مختلف
Introduction: Tuberculosis (TB) has been considered as a main health problems of the present century. Unfortunately, it has been reported different protective responses against BCG vaccine, as only available vaccine against TB .The search for a new and improved vaccine against tuberculosis is currently a very active field of research. In this study, we have evaluated the relative effects of int...
متن کاملChitosan (CHT) and trimethylchitosan (TMC) nanoparticles as adjuvant/delivery system for parenteral and nasal immunization against Mycobacterium tuberculosis (MTb) ESAT-6 antigen
Objective(s): An efficient vaccine against TB is an urgent need. TB peptides are safe candidate but they are weak immunogens and needs to be potentiated by adjuvant/delivery systems. The main purpose of the present study was to determine the potential of CHT based NPs containing ESAT-6 antigen of M. tuberculosis for inducing mucosal and systemic immune responses after intranasal and subcutaneou...
متن کاملEvaluation of Human Serological Response to Recombinant TB10.4 Antigen of Mycobacterium tuberculosis
Introduction: Development of effective immunodiagnostic methods for detection of Mycobacterium tuberculosis infection is crucial. Serodiagnostic methods, based on antibody response to specific antigens could provide promising approaches for rapid, economical and easy to perform diagnostic tests which are crucial for tuberculosis (TB) control. In this study, the level of IgG antibody responses...
متن کاملImmunogenicity of a DNA Vaccine Encoding Ag85a-Tb10.4 Antigens from Mycobacterium Tuberculosis
Background: Tuberculosis is a life threatening disease that is partially prevented by BCG vaccine. Development of more effective vaccines is an urgent priority in TB control. Ag85a and Tb10.4 are the members of culture filter protein (CFP) of M. tuberculosis that have high immunogenicity. Objective: To analyze the immunogenicity of Ag85a-Tb10.4 DNA vaccine by enzyme-linked immunosorbent as...
متن کامل